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Patients who are motivated to quit, and who did not succeed in stopping smoking during prior CHANTIX therapy for reasons other than intolerability due to adverse events or who relapsed after treatment, should be encouraged to make another attempt with CHANTIX once factors contributing to the failed attempt have been identified and addressed

Smoking contributes to the pathogenesis of pneumonia by (1) structural impairment 20 , (2) disrupting innate and adaptive immune response 21 , and (3) modifying airway microbiome 22

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